Peptide Synthesis

Unraveling the Functions of Endogenous Receptor Oligomers in the Brain Using Interfering  Peptide : The Example of D1R/NMDAR Heteromers A Andrianarivelo, E Saint-Jour, P Trifilieff… - … -Receptor Interactions in …, 2018 - Springer Decoding signaling pathways in different brain structures is crucial to develop pharmacological strategies for neurological diseases. In this perspective, the targeting of receptors by selective ligands is one of the classical therapeutic strategies. Nonetheless, this … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids ...

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59  Peptide  Bond Exhibit Unique Catalytic Properties and Substrate Specificities S Sikorra, M Skiba, M Dorner, J Weisemann, M Weil… - Toxins, 2018 - mdpi.com In the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates. BoNTs are the etiological factors of botulism and represent potential bioweapons; however … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptide...

Biomimetic Tooth Repair: Amelogenin-derived  peptide  enables in vitro remineralization of human enamel S Dogan, H Fong, DT Yucesoy, T Cousin… - ACS Biomaterials …, 2018 - ACS Publications White spot lesions (WSL) and incipient caries on enamel surfaces are the earliest clinical outcomes for demineralization and caries. If left untreated, the caries can progress and may cause complex restorative procedures or even tooth extraction which destroys soft and hard … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial P...

A new secretory  peptide  of natriuretic  peptide  family, osteocrin, suppresses the progression of congestive heart failure after myocardial infarction T Miyazaki, K Otani, A Chiba, H Nishimura… - Circulation …, 2018 - Am Heart Assoc Rationale: An increase of severe ischemic heart diseases results in an increase of the patients with congestive heart failure (CHF). Therefore, new therapies are expected in addition to recanalization of coronary arteries. Previous clinical trials using natriuretic … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, ...

[HTML]   Peptide -guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd (II)-catalyzed late-stage C–H activation J Tang, H Chen, Y He, W Sheng, Q Bai… - Nature communications, 2018 - nature.com Peptides and peptidomimetics are emerging as an important class of clinic therapeutics. Here we report a  peptide -guided method for the functionalization and macrocyclization of bioactive peptidosulfonamides by Pd (II)-catalyzed late-stage C–H activation. In this … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Pept...

[HTML]   Relationship between Perioperative N-Terminal Pro-Brain Natriuretic  Peptide  (NT-proBNP) and Complications in Thoracic Surgery K Hara, T Tsukioka, N Izumi, K Chung… - Open Journal of …, 2018 - scirp.org Background: In cardiac surgery, the N-terminal pro-brain natriuretic  peptide  (NT-proBNP) level is reportedly correlated with the onset of postoperative complications. We examined the relationship between the NT-proBNP level and perioperative complications in thoracic … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids &...

Effects of glucagon‐like  peptide ‐1 receptor agonists on cardiovascular risk factors: A narrative review of head‐to‐head comparisons NB Dalsgaard,  T Vilsbøll … - Diabetes, Obesity and …, 2018 - Wiley Online Library Cardiovascular (CV) disease is the leading cause of death and morbidity in patients with type 2 diabetes. Five CV risk factors (blood pressure, resting heart rate, body weight, cholesterol levels and blood glucose) are monitored routinely as safety and efficacy … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides,...

[HTML]   Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic  peptide  levels in patients treated at … H Naruse, J Ishii, H Takahashi, F Kitagawa… - Critical …, 2018 - ccforum.biomedcentral.com The early prediction of acute kidney injury (AKI) can facilitate timely intervention and prevent complications. We aimed to understand the predictive value of urinary liver-type fatty-acid binding protein (L-FABP) levels on admission to medical (non-surgical) cardiac intensive … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptide...

Three members of a  peptide  family are differentially distributed and elicit differential state-dependent responses in a pattern generator-effector system PS Dickinson,  MK Armstrong , ES Dickinson… - Journal of …, 2018 - physiology.org C-type allatostatins (AST-Cs) are pleiotropic neuropeptides that are broadly conserved within arthropods; the presence of three AST-C isoforms, encoded by paralog genes, is common. However, these peptides are hypothesized to act through a single receptor … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids &...

Towards a Nanoscale Description of the Interactions between Amyloid  Peptide  Aβ1-42 and Mutants with Membranes M Azouz,  C Cullin , M Lafleur, S Lecomte - Biophysical Journal, 2018 - cell.com Alzheimer's disease is considered as the major form of dementia, with an estimated number of 130 million of people living with the pathology by 2050, worldwide. In the project, we aim at determining the interactions between Alzheimer's neurotoxic  peptide  Aβ 1-42 with some … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, ...

Computation-guided rational design of a  peptide  motif that reacts with cyanobenzothiazoles via internal cysteine-lysine relay SGL Keyser, A Utz,  CR Bertozzi  - The Journal of organic chemistry, 2018 - ACS Publications Site-selective protein modification based on covalent reactions of  peptide  tags and small molecules is a key capability for basic research as well as for the development of new therapeutic bioconjugates. Here we describe the computation-guided rational design of a … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids &...

Antimicrobial  peptide  gene expression in periodontitis patients: A pilot study ML Jourdain, L Pierrard… - Journal of clinical …, 2018 - Wiley Online Library Aim Antimicrobial peptides (AMP s) are one of the most active components of innate immunity and have characteristics that could place them at the heart of the pathogenesis of periodontal disease. This study investigated differences in the expression of AMP coding … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligode...