Peptide design: Hacking hemagglutinin

Peptide design: Hacking hemagglutinin

K Kuehnel - Nature chemical biology, 2017 - nature.com
The major glycoprotein hemagglutinin (HA) binds to sialylated receptors of the host cell,
enabling endocytotic uptake of the influenza virus. Acidification in late endosomes triggers a
conformational change in the stem region of the HA homotrimer, leading to virus and host …


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