A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

R Zhang, JJ Miner, MJ Gorman, K Rausch, H Ramage… - Nature, 2016 - nature.com
Abstract Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy
is available 1, 2. We performed a genome-wide CRISPR/Cas9-based screen to identify host
genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine …


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AGTR1 Antibody

Product   AGTR1 Antibody Cat#   100-21-09A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M, R Tested Application(s)   E, WB Brief Description   Angiotensin II receptor type 1 Specific Description   Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. AGTR1, the type 1 receptor, is thought to mediate the major cardiovascular effects of angiotensin II and may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. AGTR1 has recently been found to regulate the differentiation of bone marrow-derived monocyte lineage progenitor...
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For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc. *Peptide Salt : TFA, Desalt, Acetate, HCl. *Peptide Purity : From crude to ＞99.5%. *Production Capacity : From mg to kg, with a capacity of synthesizing 15,000 peptides/month. * Peptide Library Synthesis : Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect. Quick Links: Peptide Price Peptide Modification Peptide Library Quote Request Contact Us Contact I...
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적당한운동이노화에의한포유동물면역기능의변화에미치는영향

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