[HTML] Astrocytes protect neurons from Aβ1-42 peptide-induced neurotoxicity increasing TFAM and PGC-1 and decreasing PPAR-γ and SIRT-1
[HTML] Astrocytes protect neurons from Aβ1-42 peptide-induced neurotoxicity increasing TFAM and PGC-1 and decreasing PPAR-γ and SIRT-1
D Aguirre-Rueda, S Guerra-Ojeda… - … journal of medical …, 2015 - ncbi.nlm.nih.gov
Abstract One of the earliest neuropathological events in Alzheimer's disease is accumulation
of astrocytes at sites of Aβ 1-42 depositions. Our results indicate that Aβ 1-42 toxic peptide
increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in
of astrocytes at sites of Aβ 1-42 depositions. Our results indicate that Aβ 1-42 toxic peptide
increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in
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