Peptide Synthesis

Chlorotoxin: a helpful natural scorpion  peptide  to diagnose glioma and fight tumor invasion L Dardevet, D Rani,  TAE Aziz , I Bazin, JM Sabatier… - Toxins, 2015 - mdpi.com Abstract Chlorotoxin is a small 36 amino-acid  peptide  identified from the venom of the scorpion Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to characterize chloride channels. While studying glioma-specific chloride currents, it was soon For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides...

Glucagon-Like  Peptide  1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling ,2 CC Ronveaux, D Tomé,  HE Raybould  - The Journal of nutrition, 2015 - academic.oup.com Abstract Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like  peptide  1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action of GLP-1 is on vagal afferent neurons (VANs). The vagal afferent pathway For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amy...

Peptide  bioink: self-assembling nanofibrous scaffolds for three-dimensional organotypic cultures Y Loo,  A Lakshmanan ,  M Ni , LL Toh, S Wang… - Nano …, 2015 - ACS Publications Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells and tissues. We report the first  peptide  bioinks–lysine- containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides,...

Surface tailoring for selective endothelialization and platelet inhibition via a combination of SI-ATRP and click chemistry using Cys–Ala–Gly- peptide M Khan,  J Yang , C Shi, J Lv, Y Feng, W Zhang - Acta biomaterialia, 2015 - Elsevier Abstract Surface tailoring is an attractive approach to enhancing selective endothelialization, which is a prerequisite for current vascular prosthesis applications. Here, we modified polycarbonate urethane (PCU) surface with both poly (ethylene glycol) and Cys–Ala–Gly- For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Relat...

Renal extraction and acute effects of glucagon-like  peptide -1 on central and renal hemodynamics in healthy men A Asmar, L Simonsen, M Asmar… - American Journal of …, 2015 - Am Physiological Soc The present experiments were performed to elucidate the acute effects of intravenous infusion of glucagon-like  peptide  (GLP)-1 on central and renal hemodynamics in healthy men. Seven healthy middle-aged men were examined on two different occasions in random For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides,...

α/β- Peptide  foldamers targeting intracellular protein–protein interactions with activity in living cells JW Checco, EF Lee, M Evangelista… - Journal of the …, 2015 - ACS Publications Peptides can be developed as effective antagonists of protein–protein interactions, but conventional peptides (ie, oligomers of l-α-amino acids) suffer from significant limitations in vivo. Short half-lives due to rapid proteolytic degradation and an inability to cross cell For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apeli...

[HTML]   Astrocytes protect neurons from Aβ1-42  peptide -induced neurotoxicity increasing TFAM and PGC-1 and decreasing PPAR-γ and SIRT-1 D Aguirre-Rueda, S Guerra-Ojeda… - … journal of medical …, 2015 - ncbi.nlm.nih.gov Abstract One of the earliest neuropathological events in Alzheimer's disease is accumulation of astrocytes at sites of Aβ 1-42 depositions. Our results indicate that Aβ 1-42 toxic  peptide  increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors,...

Tumor-penetrating  peptide  fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric … H Sha, Z Zou, K Xin, X Bian, X Cai, W Lu,  J Chen … - Journal of Controlled …, 2015 - Elsevier Abstract Human tumors, including gastric cancer, frequently express high levels of epidermal growth factor receptors (EGFRs), which are associated with a poor prognosis. Targeted delivery of anticancer drugs to cancerous tissues shows potential in sparing For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhib...

Humanized antibodies that recognize beta amyloid  peptide G Basi, JW Saldanha, DB Schenk - US Patent 9,051,363, 2015 - Google Patents The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies. For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc. *Peptide Salt : TFA, Desalt, Acetate, HCl. *Peptide Pur...

Alginate– peptide  amphiphile core–shell microparticles as a targeted drug delivery system J Boekhoven ,  RH Zha ,  F Tantakitti , E Zhuang, R Zandi… - RSC …, 2015 - pubs.rsc.org We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of  peptide  amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial ...

Peptide  profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains J Ebner, AA Arslan, M Fedorova, R Hoffmann… - Journal of …, 2015 - Elsevier Abstract Kefir has a long tradition in human nutrition due to its presupposed health promoting effects. To investigate the potential contribution of bioactive peptides to the physiological effects of kefir, comprehensive analysis of the  peptide  profile was performed For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Pe...

Biocatalytic Feedback‐Driven Temporal Programming of Self‐Regulating  Peptide  Hydrogels T Heuser,  E Weyandt ,  A Walther  - … Chemie International Edition, 2015 - Wiley Online Library Abstract Switchable self-assemblies respond to external stimuli with a transition between near-equilibrium states. Although being a key to present-day advanced materials, these systems respond rather passively, and do not display autonomous dynamics. For For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Pe...

Polymeric nanoparticles for co-delivery of synthetic long  peptide  antigen and poly IC as therapeutic cancer vaccine formulation S Rahimian, MF Fransen, JW Kleinovink… - Journal of Controlled …, 2015 - Elsevier Abstract The aim of the current study was to develop a cancer vaccine formulation for treatment of human papillomavirus (HPV)-induced malignancies. Synthetic long peptides (SLPs) derived from HPV16 E6 and E7 oncoproteins have been used for therapeutic For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptid...