Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

J Kwon, SR Lee, KS Yang, Y Ahn… - Proceedings of the …, 2004 - National Acad Sciences
Abstract Stimulation of cells with various peptide growth factors induces the production of
phosphatidylinositol 3, 4, 5-trisphosphate (PIP 3) through activation of phosphatidylinositol 3-
kinase. The action of this enzyme is reversed by that of the tumor suppressor PTEN. With the


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