Peptide Synthesis

Product   AGTR1 Antibody Cat#   100-21-09A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M, R Tested Application(s)   E, WB Brief Description   Angiotensin II receptor type 1 Specific Description   Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. AGTR1, the type 1 receptor, is thought to mediate the major cardiovascular effects of angiotensin II and may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. AGTR1 has recently been found to regulate the differentiation of bone marrow-derived monocyte lineage progenitor...

Product   AFAP1L2 Antibody Cat#   100-21-08A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M, R Tested Application(s)   E, WB, IHC Brief Description   Actin filament associated protein 1-like 2 protein Specific Description   AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3b, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly exp...

Product   Adiponectin Antibody Cat#   100-21-07A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M, R Tested Application(s)   E, WB, IHC Brief Description   (NT) A novel adipokine Specific Description   Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal s...

Product   ACVR1C Antibody Cat#   100-21-06A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M, R Tested Application(s)   E, WB Brief Description   Activin A receptor type IC Specific Description   Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late pha...

Product   ACVR1B Antibody Cat#   100-21-05A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M Tested Application(s)   E, WB Brief Description   Activin A receptor type IB Specific Description   Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all ...

Product   ACVR1 Antibody Cat#   100-21-04A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M Tested Application(s)   E, WB Brief Description   Activin receptor-like kinase 2 Specific Description   Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is ...

Product   Aak1 Antibody Cat#   100-21-03A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M, R Tested Application(s)   E, WB, ICC Brief Description   (NT) AP2-associated protein kinase 1 Specific Description   AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxf) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from...

Product   Aak1 Antibody Cat#   100-21-02A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M, R Tested Application(s)   E, WB Brief Description   (CT) AP2-associated protein kinase 1 Specific Description   AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxf) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the ...

Product   4E-BP1 Antibody Cat#   100-21-01A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M Tested Application(s)   E, WB, ICC Brief Description   a eukaryotic translation initiation factor Specific Description   The translation of mRNA in eukaryotic cells is regulated by the presence of amino acids through multiple mechanisms (reviewed in 1). One such mechanism involves the evolutionarily conserved serine/threonine kinase TOR (Target of rapamycin, also known as mTOR), which regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 2). One downstream target of TOR is the eukaryotic initiation factor 4E binding protein 1 (4E-BP1) whose phosphorylation prevents its association with eIF4E, preferentially stimulating translation of mRNAs containing long, highly structured 5’-UTRs (1). Rapamycin inhibits TOR resul...

Product   ACVR1C Antibody Cat#   100-21-06A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M, R Tested Application(s)   E, WB Brief Description   Activin A receptor type IC Specific Description   Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late pha...

Human α-defensin 6: a small  peptide  that self-assembles and protects the host by entangling microbes P Chairatana, EM Nolan - Accounts of chemical research, 2017 - ACS Publications Conspectus Human α-defensin 6 (HD6) is a 32-residue cysteine-rich  peptide  that contributes to innate immunity by protecting the host at mucosal sites. This  peptide  is produced in small intestinal Paneth cells, stored as an 81-residue precursor  peptide  named … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antim...

[HTML]   Glucagon-Like  Peptide -1 Receptor Agonist and Glucagon Increase Glucose-Stimulated Insulin Secretion in Beta Cells via Distinct Adenylyl Cyclases YS Lee, HS Jun - International journal of medical sciences, 2018 - ncbi.nlm.nih.gov Diabetes mellitus is a chronic disease in which the pancreas no longer produces enough insulin. Pancreatic alpha cell mass increases in response to insufficient insulin secretion. However, the reason for this increase is not clear. It is possible that the increased alpha-cells … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibito...

Scorpion toxin  peptide  action at the ion channel subunit level DM Housley, GD Housley, MJ Liddell, EA Jennings - Neuropharmacology, 2017 - Elsevier This review categorizes functionally validated actions of defined scorpion toxin (SCTX) neuropeptides across ion channel subclasses, highlighting key trends in this rapidly evolving field. Scorpion envenomation is a common event in many tropical and subtropical … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycop...

The effect of linker type and recognition  peptide  conjugation chemistry on tissue affinity and cytotoxicity of charged polyacrylamide MBD Bloch, E Yavin, A Nissan, I Ariel, R Kenett… - Journal of Controlled …, 2017 - Elsevier To increase colonoscopy competence in ambiguous situations (eg the existence of flat polyps), an explicit in situ (at real time) diagnosis at the molecular level is required. We have previously shown that the affinity of fluorescent cationic polyacrylamide (Flu-CPAA) to … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids ...

 Significance of Cardiac Involvement at Presentation in Hereditary Transthyretin-Derived Amyloidosis and the Value of N-Terminal Pro-B-Type Natriuretic  Peptide SHC Klaassen, J Tromp, HLA Nienhuis… - The American journal of …, 2018 - Elsevier The aim of this study is to assess the prevalence of cardiac involvement in hereditary transthyretin-derived (ATTRm) amyloidosis at the time of diagnosis and to determine the diagnostic and clinical value of N-terminal pro-B-type natriuretic  peptide  (NT-proBNP). The … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE ...

[HTML]   Peptide  vaccine immunotherapy biomarkers and response patterns in pediatric gliomas S Müller, S Agnihotri, KE Shoger, MI Myers, N Smith… - JCI insight, 2018 - ncbi.nlm.nih.gov Low-grade gliomas (LGGs) are the most common brain tumor affecting children. We recently reported an early phase clinical trial of a  peptide -based vaccine, which elicited consistent antigen-specific T cell responses in pediatric LGG patients. Additionally, we observed … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Pepti...

A mitochondrialtargeting  peptide  (elamipretide) prevents myocardial matrix remodeling in the infarcted zone of infarcted hearts J Shi, W Dai, R Kloner - Journal of Critical Care, 2017 - jccjournal.org Objectives: Ischemic heart failure is a complex clinical syndrome and the leading cause of mortality and morbidity worldwide. Despite considerable improvement in the treatment of heart failure in the past 20 years, the mortality of heart failure after myocardial infarction (MI) … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, ...

N-terminal pro-B-type natriuretic  peptide  and the risk of stroke among patients hospitalized with acute heart failure: an APEX trial substudy G Chi, JL Januzzi, S Korjian, Y Daaboul… - Journal of thrombosis …, 2017 - Springer Background Among patients hospitalized with acute heart failure (HF), the prognostic value of N-terminal pro-B-type natriuretic  peptide  (NT-proBNP) in short-term stroke prediction remains unclear. Methods In the APEX trial, 7513 patients hospitalized for an acute medical … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitor...