Peptide Synthesis

P2X7 receptor regulates internalization of antimicrobial  peptide  LL-37 by human macrophages that promotes intracellular pathogen clearance X Tang,  D Basavarajappa … - The Journal of …, 2015 - Am Assoc Immnol Bioactive  peptide  LL-37/hCAP18, the only human member of the cathelicidin family, plays important roles in killing various pathogens, as well as in immune modulation. We demonstrate that LL-37 is internalized by human macrophages in a time-, dose … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, An...

A pH-responsive cell-penetrating  peptide -modified liposomes with active recognizing of integrin αvβ3 for the treatment of melanoma K Shi, J Li, Z Cao, P Yang, Y Qiu, B Yang… - Journal of Controlled …, 2015 - Elsevier The use of pH-responsive cell-penetrating peptides (CPPs) is an attractive strategy for drug delivery in vivo, however, they still could not actively target to the desired sites. Here, we designed a pH-responsive CPP (TR) with the ability of active targeting to integrin α v β 3 … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Re...

[HTML]   Once‐weekly glucagon‐like  peptide ‐1 receptor agonist dulaglutide is non‐inferior to once‐daily liraglutide and superior to placebo in Japanese patients with … J Miyagawa, M Odawara, T Takamura… - Diabetes, Obesity …, 2015 - Wiley Online Library Aims To examine the efficacy and safety of once-weekly dulaglutide monotherapy (0.75 mg) compared with placebo and once-daily liraglutide (0.9 mg) in Japanese patients with type 2 diabetes. Methods This was a phase III, 52-week (26-week primary endpoint), randomized … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides ...

[HTML]   The Phe-Phe motif for  peptide  self-assembly in nanomedicine S Marchesan ,  AV Vargiu ,  KE Styan  - Molecules, 2015 - mdpi.com Since its discovery, the Phe-Phe motif has gained in popularity as a minimalist building block to drive the self-assembly of short peptides and their analogues into nanostructures and hydrogels. Molecules based on the Phe-Phe motif have found a range of applications in … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendro...

Facile fabrication of diphenylalanine  peptide  hollow spheres using ultrasound-assisted emulsion templates Q Li ,  H Ma , Y Jia,  J Li , B Zhu - Chemical Communications, 2015 - pubs.rsc.org The controlled self-assembly of diphenylalanine (FF) into unilocular and multilocular hollow spheres was successfully achieved by an ultrasound-assisted emulsion droplet template method. This novel surfactant-free emulsion droplet template method is envisaged to be … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial P...

[HTML]   Treatment of oral multispecies biofilms by an anti-biofilm  peptide Z Wang,  C de la Fuente-Núñez , Y Shen, M Haapasalo… - PloS one, 2015 - journals.plos.org Human oral biofilms are multispecies microbial communities that exhibit high resistance to antimicrobial agents. Dental plaque gives rise to highly prevalent and costly biofilm-related oral infections, which lead to caries or other types of oral infections. We investigated the … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin P...

A type of auxiliary for native chemical  peptide  ligation beyond cysteine and glycine junctions SF Loibl, Z Harpaz,  O Seitz  - Angewandte Chemie International …, 2015 - Wiley Online Library Native chemical ligation enables the chemical synthesis of proteins. Previously, thiol- containing auxiliary groups have been used to extend the reaction scope beyond N-terminal cysteine residues. However, the N-benzyl-type auxiliaries used so far result in rather low … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobi...

Drug delivery with nanospherical supramolecular cell penetrating  peptide –taxol conjugates containing a high drug loading R Tian,  H Wang , R Niu, D Ding - Journal of colloid and interface science, 2015 - Elsevier Hypothesis Supramolecular nanostructures via small molecule self-assembly hold great promise for controlled delivery of hydrophobic anticancer drugs. Particularly, taxol has recently been discovered to possess excellent self-assembly property, which may provide … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antim...

Radiolabeled cyclic RGD  peptide  bioconjugates as radiotracers targeting multiple integrins S Liu - Bioconjugate chemistry, 2015 - ACS Publications Angiogenesis is a requirement for tumor growth and metastasis. The angiogenic process depends on vascular endothelial cell migration and invasion, and is regulated by various cell adhesion receptors. Integrins are such a family of receptors that facilitate the cellular … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte...

Nanoparticle-mediated delivery of the antimicrobial  peptide  plectasin against Staphylococcus aureus in infected epithelial cells JJ Water, S Smart,  H Franzyk ,  C Foged … - European Journal of …, 2015 - Elsevier A number of pathogenic bacterial strains, such as Staphylococcus aureus, are difficult to kill with conventional antibiotics due to intracellular persistence in host airway epithelium. Designing drug delivery systems to deliver potent antimicrobial peptides (AMPs) … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Relat...

Liquid-crystalline ordering of antimicrobial  peptide –DNA complexes controls TLR9 activation NW Schmidt , F Jin, R Lande,  T Curk ,  W Xian ,  C Lee … - Nature materials, 2015 - nature.com Double-stranded DNA (dsDNA) can trigger the production of type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by binding to endosomal Toll-like receptor-9 (TLR9; refs 1, 2, 3, 4, 5). It is also known that the formation of DNA–antimicrobial  peptide  complexes can … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptide...

Heterozygous Mutations in Natriuretic  Peptide  Receptor‐B (NPR2) Gene as a Cause of Short Stature SR Wang, CM Jacobsen, H Carmichael… - Human …, 2015 - Wiley Online Library Based on the observation of reduced stature in relatives of patients with acromesomelic dysplasia, Maroteaux type (AMDM), caused by homozygous or compound heterozygous mutations in natriuretic  peptide  receptor-B gene (NPR2), it has been suggested that … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides...