Peptide Synthesis

A novel GIP analogue, ZP 4165, enhances glucagon‐like  peptide ‐1‐induced body weight loss and improves glycaemic control in rodents PK Nørregaard, MA Deryabina… - Diabetes, Obesity …, 2018 - Wiley Online Library Aim To investigate the effects of the novel glucose‐dependent insulinotropic polypeptide (GIP) analogue, ZP 4165, on body weight and glycaemic control in rodents, and to investigate if ZP 4165 modulates the anti‐obesity and anti‐hyperglycaemic effects of a … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobia...

Racial differences in plasma levels of N-terminal pro–B-type natriuretic  peptide  and outcomes: the Reasons for Geographic and Racial Differences in Stroke … NS Bajaj ,  OM Gutierrez , G Arora, SE Judd… - JAMA …, 2018 - jamanetwork.com Importance Recent studies have suggested that the natriuretic  peptide  system may be endogenously suppressed in black individuals who are free of prevalent cardiovascular disease. Whether natriuretic  peptide  levels contribute to racial disparities in clinical … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptide...

Persistent Hematologic Dysfunction after  Peptide  Receptor Radionuclide Therapy with 177Lu-DOTATATE: Incidence, Course, and Predicting Factors in Patients with … H Bergsma, K van Lom… - Journal of Nuclear …, 2018 - Soc Nuclear Med Peptide  receptor radionuclide therapy (PRRT) may induce long-term toxicity to the bone marrow (BM). The aim of this study was to analyze persistent hematologic dysfunction (PHD) after PRRT with 177 Lu-DOTATATE in patients with gastroenteropancreatic neuroendocrine … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Am...

Comparison of carbohydrate antigen 125 and N-terminal pro-brain natriuretic  peptide  for risk prediction after transcatheter aortic valve implantation T Rheude, C Pellegrini, H Schmid… - American journal of …, 2018 - ajconline.org Elevated carbohydrate antigen 125 (CA125) and N-terminal pro-brain natriuretic  peptide  (NTproBNP) have been associated with adverse outcome after transcatheter aortic valve implantation (TAVI). This study performs a comparison of both biomarkers for prognosis after … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, ...

Redox sensitive PEG controlled octaarginine and targeting  peptide  co-modified nanostructured lipid carriers for enhanced tumour penetrating and targeting in vitro … H Wang, M Sun, D Li, X Yang, C Han… - Artificial cells …, 2018 - Taylor & Francis To strengthen the anti-tumour efficacy and weaken the side effects, a nano targeted drug delivery system was constructed. The nanostructured lipid carriers (NLCs) were prepared by the melt-emulsification method. Modified with the octaarginine, thiolytic cleavable … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE ...

Validation of immunomonitoring methods for application in clinical studies: The HLA‐ peptide  multimer staining assay PA Chandran, K Laske, A Cazaly… - Cytometry Part B …, 2018 - Wiley Online Library Background Validated assays are essential to generate data with defined specificity, consistency, and reliability. Although the process of validation is required for applying immunoassays in the context of clinical studies, reports on systematic validation of in vitro T … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobi...

T cells specific for a TAP-independent self- peptide  remain naïve in tumor-bearing mice and are fully exploitable for therapy EM Doorduijn, M Sluijter, KA Marijt, BJ Querido… - …, 2018 - Taylor & Francis Cancers frequently evade immune-recognition by lowering  peptide : MHC-I complexes on their cell surface. Limited  peptide  supply due to TAP-deficiency results in such MHC-Ilow immune-escape variants. Previously, we reported on a category of TAP-independent self … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides,...

miR-204 controls Glucagon-like  Peptide  1 Receptor expression and agonist function SH Jo, J Chen, G Xu, TB Grayson, LA Thielen… - Diabetes, 2018 - Am Diabetes Assoc Glucagon-like  peptide  1 receptor (GLP1R) agonists are widely used to treat diabetes. However, their function is dependent on adequate GLP1R expression, which is downregulated in diabetes. GLP1R is highly expressed on pancreatic β-cells, and activation … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Olig...

Effects of different force fields on the structural character of α synuclein β-hairpin  peptide  (35–56) in aqueous environment S Kundu - Journal of Biomolecular Structure and Dynamics, 2018 - Taylor & Francis The hallmark of Parkinson's disease (PD) is the intracellular protein aggregation forming Lewy Bodies (LB) and Lewy neuritis which comprise mostly of a protein, alpha synuclein (α- syn). Molecular dynamics (MD) simulation methods can augment experimental techniques … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, An...

Phase I study of glypican-3-derived  peptide  vaccine therapy for patients with refractory pediatric solid tumors N Tsuchiya, A Hosono, T Yoshikawa, K Shoda… - …, 2018 - Taylor & Francis The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer immunotherapy against pediatric solid tumors expressing GPC3. In this non-randomized, open-label, phase I clinical trial, we analyzed the safety and efficacy of GPC3- peptide   … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin ...

Quaternary β 2,2 ‐Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc‐Based Solid‐Phase  Peptide  Synthesis JS Yu, H Noda, M Shibasaki - Angewandte Chemie, 2018 - Wiley Online Library Abstract β‐Amino acid incorporation has emerged as a promising approach to enhance the stability of parent peptides and to improve their biological activity. Owing to the lack of reliable access to β2, 2‐amino acids in a setting suitable for  peptide  synthesis, most … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Relate...

Phage Display Selection,  In Vitro  Characterization, and Correlative PET Imaging of a Novel HER3  Peptide BM Larimer, N Phelan, E Wehrenberg-Klee… - Molecular Imaging and …, 2018 - Springer Abstract Purpose HER3 (ERBB3) is a receptor tyrosine kinase that is implicated in treatment resistance across multiple cancers, including those of the breast, lung, and prostate. Overexpression of HER3 following targeted therapy can occur rapidly and heterogeneously … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial ...

Identification and characterization of an angiotensin-converting enzyme inhibitory  peptide  derived from bovine casein L Xue, X Wang, Z Hu, Z Wu, L Wang, H Wang, M Yang - Peptides, 2018 - Elsevier In this study, we identified a novel angiotensin-I-converting enzyme (ACE) inhibitory  peptide , YQKFPQYLQY (YQK), derived from bovine casein. Casein was hydrolyzed using pepsin and trypsin. The target  peptide , YQK, was separated from the hydrolysate by ultrafiltration and … For custom peptides, please visit  www.pepmic.com . Our peptide services including but not limited to: *Peptide Synthesis : From short peptides to long peptides, linear peptides to cyclic peptides. * Peptide Modifications : Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc. *Catalog Peptides : ACE Inhibitors, Amyloids & Related Peptides...