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AGTR1 Antibody

Product   AGTR1 Antibody Cat#   100-21-09A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M, R Tested Application(s)   E, WB Brief Description   Angiotensin II receptor type 1 Specific Description   Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. AGTR1, the type 1 receptor, is thought to mediate the major cardiovascular effects of angiotensin II and may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. AGTR1 has recently been found to regulate the differentiation of bone marrow-derived monocyte lineage progenitor...
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AFAP1L2 Antibody

Product   AFAP1L2 Antibody Cat#   100-21-08A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M, R Tested Application(s)   E, WB, IHC Brief Description   Actin filament associated protein 1-like 2 protein Specific Description   AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3b, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly exp...
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Adiponectin Antibody

Product   Adiponectin Antibody Cat#   100-21-07A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M, R Tested Application(s)   E, WB, IHC Brief Description   (NT) A novel adipokine Specific Description   Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal s...
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ACVR1C Antibody

Product   ACVR1C Antibody Cat#   100-21-06A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M, R Tested Application(s)   E, WB Brief Description   Activin A receptor type IC Specific Description   Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late pha...
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ACVR1B Antibody

Product   ACVR1B Antibody Cat#   100-21-05A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M Tested Application(s)   E, WB Brief Description   Activin A receptor type IB Specific Description   Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all ...
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ACVR1 Antibody

Product   ACVR1 Antibody Cat#   100-21-04A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M Tested Application(s)   E, WB Brief Description   Activin receptor-like kinase 2 Specific Description   Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is ...
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Aak1 Antibody

Product   Aak1 Antibody Cat#   100-21-03A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M, R Tested Application(s)   E, WB, ICC Brief Description   (NT) AP2-associated protein kinase 1 Specific Description   AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxf) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from...
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